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Mild CNS toxicity manifests as restlessness, irritability, and sedation. Although not yet available in the US, it allows for once daily dosing, although again on inducing drugs needs to be dosed more than once per day. They also found that serum lithium concentrations were significantly higher in patients with severe neurotoxicity (2.

Double-blind, placebo-controlled trials support the use of lamotrigine as prophylaxis against future episodes. Correlating lamotrigine serum concentrations with tolerability in patients with epilepsy. Most clinicians adhere to the package insert, and maintain lithium serum lithium levels to between 0. Rash almost always occurs in the first 8 weeks of therapy and is commonly related to concomitant anti-epileptic medication, specifically valproic acid. The largest single class of drugs that would produce a clinically significant interaction with lithium is the diuretics.

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Although lamotrigine does not affect the metabolism of other drugs, its own metabolism and side-effect profile is significantly affected by other medications. A randomised double-blind placebo-controlled crossover add-on trial of lamotrigine in patients with treatment-resistant partial seizures. Lawn maintenance and home repairs are all taken care of.

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